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Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm [PS_CUTnRUN]

ABSTRACT: We discovered a role for the transcription factor OTX2 in formation of mouse definitive endoderm (DE). We used CUT&RUN to map OTX2-bound genomic regions and identify OTX2-regulated genes during directed differentiation of EpiSCs to DE

ORGANISM(S): Mus musculus

PROVIDER: GSE294520 | GEO | 2025/07/21

REPOSITORIES: GEO

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Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm.

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