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Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 to establish T cell niches

ABSTRACT: Secondary lymphoid organs are structurally organized by fibroblastic reticular cells (FRCs), which support immune cell positioning and adaptive immune responses. However, the mechanisms driving the differentiation of FRCs into distinct functional subsets remain unclear. To investigate the role of Notch2 signaling in this process, we performed single-cell RNA sequencing (10x Genomics) on lymph node FRCs lacking Notch2 expression. Our dataset highlights how this pathway contributes to FRC differentiation.

ORGANISM(S): Mus musculus

PROVIDER: GSE294697 | GEO | 2026/04/22

REPOSITORIES: GEO

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Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 to establish T cell niches

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