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Adipocyte-specific deletion of gp130 prevents ketogenic AQ1 diet–induced hepatic steatosis

ABSTRACT: Metabolic dysfunction-associated fatty liver disease (MASLD), the hepatic manifestation of obesity and type 2 diabetes (T2D), can progress to metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis. MASLD is characterized by elevated hepatic lipid accumulation (steatosis) and insulin resistance. Ketogenic diet (KD), a high-fat, low-carbohydrate diet, induces hepatic insulin resistance and steatosis in animal models through unknown mechanisms. Our studies demonstrate the importance of adipose tissue-liver crosstalk in mediating MASLD progression and identify adipocyte IL-6-gp130 as a potential therapeutic target.

ORGANISM(S): Mus musculus

PROVIDER: GSE294746 | GEO | 2025/08/07

REPOSITORIES: GEO

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Adipocyte-specific deletion of gp130 prevents ketogenic AQ1 diet–induced hepatic steatosis

Project description:Adipocyte-specific deletion of gp130 prevents ketogenic AQ1 diet–induced hepatic steatosis

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