Transcriptomics

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MiR-29 enables immune evasion of colon cancer by regulating fucosylation-mediated Ras-GTP signal in CD8+ T cells


ABSTRACT: Immune checkpoint blockade (ICB) therapies such as PD-1 antibodies has shown remarkable clinical success in the control of tumor growth, yet only a fraction of patients benefits from such therapy. As a result, there is increasing interest in boosting the effectiveness of ICB by combining it with other treatments. Objectives: Screening critical microRNAs that inhibit colon tumor growth in concert with ICB based on the effectiveness of immunotherapy and the gene expression levels in colorectal patients and revealing the regulatory mechanism.

ORGANISM(S): Mus musculus

PROVIDER: GSE295030 | GEO | 2025/07/31

REPOSITORIES: GEO

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