A Natural Cyclic Peptide Enhances Cytotoxic Th9 Differentiation and Antitumor Immunity

ABSTRACT: Adoptive cell therapy (ACT) relies on durable and functional T cells to mediate tumor clearance. Th9 cells are a metabolically fit CD4⁺ T cell subset with strong persistence but limited cytotoxicity. Here, we identify Endomelipaneptide A (EpA), a cyclic peptide from Ganoderma lucidum–associated endophytic fungi, as a potent enhancer of Th9 differentiation. EpA promotes a cytotoxic Th9 phenotype with enhanced mitochondrial function and metabolic fitness.

ORGANISM(S): Mus musculus

PROVIDER: GSE295054 | GEO | 2025/11/28

REPOSITORIES: GEO