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Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [RNA-seq]

ABSTRACT: To investigate the role UTX (KDM6A) in stratifying epithelia

ORGANISM(S): Mus musculus

PROVIDER: GSE295058 | GEO | 2025/05/22

REPOSITORIES: GEO

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Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [Xenium]

Project description:To investigate the role UTX (KDM6A) in stratifying epithelia

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Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [ChIP-seq]

Project description:To investigate the role UTX (KDM6A) in stratifying epithelia

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Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [CUT&RUN]

Project description:To investigate the role UTX (KDM6A) in stratifying epithelia

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Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [Xenium]

Project description:Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [Xenium]

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Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [CUT&RUN]

Project description:Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [CUT&RUN]

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Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [ChIP-seq]

Project description:Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [ChIP-seq]

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Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [RNA-seq]

Project description:Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [RNA-seq]

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Alternative mRNA splicing controls functions of the human H3K27 demethylase UTX/KDM6A

Project description:The UTX/KDM6A gene encodes the UTX histone H3K27 demethylase, which plays an important role in mammalian development and is frequently mutated in cancers and particularly, in urothelial cancers. Using BioID technique, we explored the interactome of different UTX isoforms.

2024-01-28 | PXD041254 | Pride

Small Cell Lung Cancer Subtype Plasticity is Regulated by KDM6A/UTX [RNA-Seq]

Project description:Using a CRISPR-based autochthonous SCLC GEMM to study the consequences of KDM6A/UTX inactivation, we found that KDM6A inactivation induced plasticity from ASCL1 to NEUROD1 resulting in SCLC tumors with open chromatin at the NEUROD1 promoter that express both ASCL1 and NEUROD1. Mechanistically, KDM6A binds and maintains ASCL1 target genes in an active chromatin state with its loss increasing H3K27me3 near their promoters leading to a cell state that is primed for ASCL1 to NEUROD1 subtype switching. This work identifies KDM6A as an epigenetic regulator that controls ASCL1 to NEUROD1 subtype plasticity and provides a novel autochthonous SCLC GEMM to model ASCL1 and NEUROD1 subtype heterogeneity and plasticity, which is found in 35-40% of human SCLCs.

2023-06-09 | GSE211160 | GEO

RNA-Sequencing of primary myoblasts from mice with a satellite cell specific knockout of the histone demthylase UTX/KDM6A

Project description:The KDM6 histone demethylases (UTX/KDM6A and JMJD3/KDM6B) mediate removal of repressive histone H3K27me3 marks to establish transcriptionally permissive chromatin. Loss of UTX in female mice is embryonic lethal. Unexpectedly, male UTX-null mice escape embryonic lethality due to expression of UTY, a paralog lacking H3K27-demethylase activity. This suggests that UTX plays an enzyme-independent role in development, and challenges the need for active H3K27-demethylation in vivo. However, the requirement for active H3K27-demethylation in stem cell-mediated tissue regeneration remains untested. Using an inducible mouse knockout that ablates UTX in satellite cells, we show that active H3K27-demethylation is necessary for muscle regeneration. Indeed, loss of UTX in satellite cells blocks myofiber regeneration in both male and female mice. Furthermore, we demonstrate that UTX mediates muscle regeneration through its H3K27-demethylase activity using a chemical inhibitor, and a demethylase-dead UTX knock-in mouse. Mechanistically, dissection of the muscle regenerative process revealed that UTX is required for expression of the transcription factor Myogenin that drives differentiation of muscle progenitors. Thus, we have identified a critical role for the enzymatic activity of UTX in activating muscle-specific gene expression during myofiber regeneration, revealing for the first time that active H3K27-demethylation has a physiological role in vivo. Satellite cells were sorted based on Cre-dependent expression of TdT reporter gene. Sorted UTXmKO or UTX WT satellite cells were then induced to differentiate for 24 hrs. RNA was then isolated and subjected to RNA-Seq analysis.

2016-03-22 | E-GEOD-69968 | biostudies-arrayexpress

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