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Identification of differentially expressed genes involved in the enhancement of mild hyperthermia sensitivity by chroloquine in HSC-3 human oral squamous cell carcinoma cells.

ABSTRACT: Hyperthermia (HT) is an effective treatment for cancer. When combined with chemotherapy, radiotherapy, or both, HT is expected to show high therapeutic efficacy against various tumors. Chloroquine (CQ), a clinically used treatment for malaria, has been found to inhibit autophagy. CQ has also been reported to enhance thermosensitivity in cancer cells. However, the molecular mechanisms underlying CQ-induced enhancement of thermosensitivity remain unclear. Here, we identified the differentially expressed genes involved in the enhancement of mild HT (MHT) sensitivity by chroloquine in HSC-3 human oral squamous cell carcinoma (OSCC) cells using GeneChip oligonucleotide microarrays.

ORGANISM(S): Homo sapiens

PROVIDER: GSE295102 | GEO | 2025/05/10

REPOSITORIES: GEO

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Identification of genes responsive to mild hyperthermia in human oral squamous cell carcinoma HSC-3 cells

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