Differential microRNA profiles associated with the hydroxyurea-inducible SAR1A gene

ABSTRACT: We used small-RNA sequencing to carry out the first comprehensive survey of miRNAs expressed in SAR1A-knockout K562 cells without or with HU treatment and assessed their potential functions related to HbF induction. our findings suggest a profile of dysregulated miRNAs associated with SAR1A downregulation which may influence HbF expression directly or indirectly targeting the transcription factors linked to gamma-globin gene regulation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE295109 | GEO | 2025/06/23

REPOSITORIES: GEO