Targeting Regnase-1 unleashes CAR T cell antitumor activity for osteosarcoma and creates a proinflammatory tumor microenvironment [scRNAseq2]

ABSTRACT: We took advantage of CAR T cells targeting B7-H3 in immune competent osteosarcoma models and evaluated the intrinsic and extrinsic effects of the known negative regulator Regnase-1 (Reg-1).

ORGANISM(S): Mus musculus

PROVIDER: GSE295138 | GEO | 2026/07/14

REPOSITORIES: GEO