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Single-Cell Transcriptomic Profiling of Male Zebrafish Pituitary: Investigating the Impact of CCK1/CCK2 Knockout on Pituitary Function

ABSTRACT: This study explores the effects of CCK1 and CCK2 knockout on the pituitary of male zebrafish using single-cell RNA sequencing (scRNA-seq). Two groups were analyzed: the CCK1/CCK2 knockout (KO) group and the wild-type (WT) group. Pituitary tissues were dissociated into single cells, followed by RNA sequencing to examine changes in gene expression. The results show how CCK receptor loss impacts pituitary cell function and gene expression, providing insights into the role of CCK in zebrafish pituitary regulation and endocrine function.

ORGANISM(S): Danio rerio

PROVIDER: GSE295139 | GEO | 2026/04/03

REPOSITORIES: GEO

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