Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptome profiling of CT26 cells and differentiated CT26 cells induced by knockdown of Setdb1 using RNA-sequencing.

ABSTRACT: The core proeprty of cancer cells is neural stemness, which determines tumorigenicity and pluripotency. Therefore, cancer cells can supposedly be induced to differentiate along different lineages. CT26 is a mouse colon cancer cell line. Setdb1 is an epigenetic modification factor responsible for catalyzing the histone modification H3K9me3. Transcription of Setdb1 gene is enriched in embryonic neural cells during vertebrate embryogenesis. Setdb1 is upregulated in cancer cells and promotes cancers. We found that knockdown of Setdb1 in CT26 cells led to a neuronal-like differentiation phenotype.

ORGANISM(S): Mus musculus

PROVIDER: GSE295154 | GEO | 2026/06/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Transcriptome profiling of CT26 cells and differentiated CT26 cells induced by forced expresssion of Myod1 or Pparg using RNA-sequencing.

2026-06-01 | GSE295153 | GEO

Transcriptome profiling of SKHEP1 cells and differentiated SKHEP1 cells induced by knockdown of SETDB1 using RNA-sequencing

Project description:The core proeprty of cancer cells is neural stemness, which determines tumorigenicity and pluripotency. Therefore, cancer cells can supposedly be induced to differentiate along different lineages. SKHEP1 is a human hepatocellular carcinoma cell line. SETDB1 is an epigenetic modification factor responsible for catalyzing the histone modification H3K9me3. Transcription of SETDB1 gene is enriched in embryonic neural cells during vertebrate embryogenesis. SETDB1 is upregulated in cancer cells and promotes cancers. We found that knockdown of SETDB1 in SKHEP1 cells led to a neuronal-like differentiation phenotype.

2026-06-01 | GSE295159 | GEO

Transcriptome profiling of B16F10 cells and differentiated B16F10 cells induced by forced expresssion of Myod1, Pparg, or by knockdown of Setdb1 using RNA-sequencing.

Project description:The core proeprty of cancer cells is neural stemness, which determines tumorigenicity and pluripotency. Therefore, cancer cells can supposedly be induced to differentiate along different lineages. B16F10 is a mouse melanoma cell line. We found that B16F10 cells differentiated into muscle cells or adipocytes upon induction by muscle or adipocyte differentiation factor Myod1 or Pparg, respectively. Moreover, Setdb1 is an epigenetic modification factor responsible for catalyzing the histone modification H3K9me3. Transcription of Setdb1 gene is enriched in embryonic neural cells during vertebrate embryogenesis. Setdb1 is upregulated in cancer cells and promotes cancers. We found that knockdown of Setdb1 in B16F10 cells led to a neuronal-like differentiation phenotype.

2026-06-01 | GSE295152 | GEO

Transcriptome profiling of CT26 cells and de-differentiated CT26 cells induced by forced expresssion of Oct4 and SOX2 using RNA-sequencing.

Project description:The core proeprty of cancer cells is neural stemness, which determines tumorigenicity and pluripotency. It has been reported that neural stem cells are uniquely immune-privileged, suggesting that neural stemness also confers cancer cells with the ability of immune evasion or immune privilege. CT26 is a mouse colon cancer cell line. We found that dedifferentiation of CT26 cells with overexpression of Oct4 and SOX2 enhanced neural stemness and decreased immunogenicity in cells.

2026-05-31 | GSE298039 | GEO

Identification of Setdb1 interaction proteins in neural stem cells

Project description:Setdb1 is an epigenetic factors catalyzing modification of H3K9me3. Expression of its gene is localized to embryonic neural cells during vertebrate embryogenesis, suggesting its role in regulating neural stemness. The project is to identify the interaction partners of Setdb1, by which Setdb1 regulates neural stemness in neural stem cells.

2022-08-12 | PXD030453 | Pride

Transcriptome profiling of SKHEP1 cells and differentiated SKHEP1 cells induced by forced expresssion of PPARG using RNA-sequencing.

2026-06-01 | GSE295158 | GEO

Transcriptome profiling of HCT116 cells and HCT116 cells with knockdown of SETDB1 by RNA-sequencing

Project description:HCT116 is a colorectal cancer cell line. SETDB1 is an epigenetic modification factor responsible for catalyzing the histone modification H3K9me3. Transcription of SETDB1 gene is enriched in embryonic neural cells during vertebrate embryogenesis. SETDB1 is upregulated in cancer cells and promotes cancers. We found that knockdown of SETDB1 in HCT116 cells led to a neuronal-like differentiation phenotype.

2022-06-30 | GSE192372 | GEO

Transcriptome profiling of SKHEP1 cells and differentiated SKHEP1 cells induced by forced expresssion of MYOD1 using RNA-sequencing.

2026-06-01 | GSE295157 | GEO

Transcriptome profiling of NE-4C cells and NE-4C cells with knockdown of Setdb1 by RNA-sequencing

Project description:NE-4C is a mouse neural stem cell line used for study of neuronal differentiation. Setdb1 is an epigenetic modification factor responsible for catalyzing the histone modification H3K9me3. Transcription of Setdb1 gene is enriched in embryonic neural cells during vertebrate embryogenesis. Setdb1 is upregulated in cancer cells and promotes cancers. We found that knockdown of Setdb1 in NE-4C cells led to neuronal differentiation.

2022-06-30 | GSE192373 | GEO

Transcriptome profiling of HCT116 cells and differentiated HCT116 cells induced by forced expresssion of MYOD1 or PPARG using RNA-sequencing.

2026-06-01 | GSE295155 | GEO