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Effects of TCF-1 de-repression on heterogeneity of chromatin states in memory and effector cells following acute infecton [scATAC-seq]

ABSTRACT: The transcription factor TCF-1 is downregulated during effector differentiation of CD8+ T cells. However, how its downregulation impacts epigenetic regulation of different effector- and memory-biased populations remains unclear. Here, we generate mice in which TCF-1 fails to become downregulated in differentiated effector cells and probe the epigenetic impact of TCF-1 retention on gene accessibiltiy patterns and moif enrichment patterns in CD8+ T cells on 8 dpi with LCMV-13 using scATAC-seq.

ORGANISM(S): Mus musculus

PROVIDER: GSE295247 | GEO | 2025/05/31

REPOSITORIES: GEO

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Effects of TCF-1 de-repression on heterogeneity of effector and memory progenitor T cell transcriptomes in acute infection [scRNA-seq]

Project description:The transcription factor TCF-1 is downregulated during effector differentiation of CD8+ T cells. However, how its downregulation impacts gene expression in different effector- and memory-biased populations remains unclear. Here, we generate mice in which TCF-1 fails to become downregulated in differentiated effector cells and probe the transcriptional impact of TCF-1 retention in different T cell differentiation states by scRNA-sequencing.

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