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Hepatocyte-derived Pumilio1-enriched exosomes inhibit hepatic stellate cell activation by suppressing tropomyosin-4 translation

ABSTRACT: Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease globally. Abnormal crosstalk between hepatocytes and hepatic stellate cells (HSCs) leads to liver fibrosis and aggravates MASLD. We explored the role of the RNA-binding protein Pumilio in this process.

ORGANISM(S): Homo sapiens

PROVIDER: GSE295362 | GEO | 2025/04/27

REPOSITORIES: GEO

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Hepatic miR-93 promotes the pathogenesis of metabolic dysfunction-associated steatotic liver disease by suppressing SIRT1

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Hepatocyte-derived Pumilio1-enriched exosomes inhibit hepatic stellate cell activation by suppressing tropomyosin-4 translation

Project description:Hepatocyte-derived Pumilio1-enriched exosomes inhibit hepatic stellate cell activation by suppressing tropomyosin-4 translation

| PRJNA1254274 | ENA

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