Persistence of alveolar fibroblast-derived ADAMTS4+ cells during delayed resolution of pulmonary fibrosis

ABSTRACT: Idiopathic pulmonary fibrosis is a severe interstitial lung disease with limited therapeutic options. This study traced fibroblast growth factor 10 (Fgf10+) alveolar fibroblasts (AFs) in aged mice subjected to bleomycin injury, analyzing histology and single-cell transcriptomics at peak fibrosis and during resolution phases. Ex vivo models and human lung tissue data were also examined. Results showed Fgf10+ AFs transitioning from lipofibroblasts (LIF) to myofibroblasts (MyoFBs) during fibrogenesis, and reversing during resolution. An ADAM metallopeptidase with thrombospondin type 1 motif 4 (Adamts4+) AF population was linked to delayed resolution. ADAMTS4 emerged as a key target in fibrotic lung diseases, highlighting its therapeutic potential.

ORGANISM(S): Mus musculus

PROVIDER: GSE295566 | GEO | 2026/02/20

REPOSITORIES: GEO