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Single-Cell Transcriptomic Profiling of Male Zebrafish hypothalamus: Investigating the Impact of CCK1/CCK2 Knockout on hypothalamus Function

ABSTRACT: This study explores the effects of CCK1 and CCK2 knockout on the hypothalamus of male zebrafish using single-cell RNA sequencing (scRNA-seq). Two groups were analyzed: the CCK1/CCK2 knockout (KO) group and the wild-type (WT) group. hypothalamus tissues were dissociated into single cells, followed by RNA sequencing to examine changes in gene expression. The results show how CCK receptor loss impacts hypothalamus cell function and gene expression, providing insights into the role of CCK in zebrafish hypothalamus regulation and endocrine function.

ORGANISM(S): Danio rerio

PROVIDER: GSE296008 | GEO | 2026/04/03

REPOSITORIES: GEO

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