ARP-1 wild-type and ARP-1 carfilzomib-resistant cells RNA-seq analysis

ABSTRACT: Proteasome inhibitors (PIs) such as carfilzomib (Cfz) are highly efficacious for patients with Multiple myeloma (MM). However, relapses and acquired resistance to PI treatment emerges in most patients. Here, we established Cfz-resistant MM cells. RNA-seq analysis revealed significant alterations in cholesterol- and lipid-related metabolic pathways in the resistant cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE296076 | GEO | 2026/07/01

REPOSITORIES: GEO