NHR-66 Regulates Cuticular Collagen Expression and Modulates C. elegans Adhesion to Predatory Fungi

ABSTRACT: NHR-66, a nuclear hormone receptor in C. elegans, regulates cuticle collagen genes important for fungal adhesion. RNA-seq of wild-type and nhr-66 STOP-IN mutants exposed to Arthrobotrys oligospora revealed >1200 genes downregulated in mutants, including over 40% of the collagen gene family. GO analysis highlighted enrichment in cuticle structure terms.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE296207 | GEO | 2025/05/09

REPOSITORIES: GEO