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Effects of hyperbaric oxygen on tissue-specific aging and senescence in mice and human stromal cells

ABSTRACT: This study investigates the effects of hyperbaric oxygen (HBO) on cellular senescence and aging-related phenotypes. In naturally aged mice, HBO treatment reduced systemic senescence burden and reversed aging-related transcriptomic signatures in skin, liver, and kidney tissues. Additionally, single-session HBO exposure was shown to preferentially suppress SASP propagation in human stromal cells. This dataset includes transcriptomic profiles of skin, liver, and kidney tissues from young, aged, and HBO-treated aged mice, as well as human primary prostate stromal cells (PSC27).

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE296209 | GEO | 2025/05/09

REPOSITORIES: GEO

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Gene expression analysis of bleomycin-challenged mouse lung tissues with/without repetitive hyperbaric oxygen treatment

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Hyperbaric oxygen therapy after mid-cervical spinal contusion injury

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Mouse lung gene expression analysis after repetitive hyperbaric oxygen exposure based on RNA-seq

Project description:Hyperbaric oxygen (HBO) is widely applied to treat a number of hypoxia-related diseases. Previous studies focused on the immediate effect of HBO-exposure induced oxidative stress on lungs, but knowledge regarding the chronic effects from repetitive HBO exposure is limited, especially at the gene expression level. We found that repetitive HBO exposure did not alter the morphology of murine lungs. However, by deconvolution of RNA-seq from those mice lungs using CIBERSORTx and the expression profile matrices of 8 mesenchymal cell subtypes obtained from bleomycin-treated mouse lungs, we identify several mesenchymal cell subtype changes. These include increases in Col13a1 matrix fibroblasts, mesenchymal progenitors and mesothelial cell populations and decreases in lipofibroblasts, endothelial and Pdgfrb high cell populations. Our data suggest that repetitive HBO exposure may affect biological processes in the lungs such as response to wounding, extracellular matrix, vasculature development and immune response.

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Analysis of long noncoding RNAs expression profiles explores mechanisms of hyperbaric oxygen treatment promoting spinal cord injury recovery

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Effect of Hyperbaric Oxygen and Inflammation on Human Gingival Mesenchymal Stem/Progenitor Cells

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Effects of hyperbaric oxygen on tissue-specific aging and senescence in mice and human stromal cells

Project description:Effects of hyperbaric oxygen on tissue-specific aging and senescence in mice and human stromal cells

| PRJNA1258211 | ENA

A tumor-stroma interaction study

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2011-06-01 | E-TABM-1103 | biostudies-arrayexpress

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