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ZFP148 is a transcriptional regulator of effector CD8+ T cell differentiation

ABSTRACT: In the setting of chronic antigen stimulation, such as chronic viral infection and cancer, antigen-specific CD8+ T cells differentiate into a heterogeneous pool of progenitor/stem-like, effector, and exhausted/dysfunctional subsets. Though genetic and epigenetic programs that contribute to the generation of each subset have been reported, how these subsets are dynamically regulated and how their balance can be shifted from exhausted toward cytolytic effector cells remain as outstanding questions. Here, we identified Zinc-Finger Protein 148 (ZFP148) as a novel transcriptional checkpoint for CD8+ T cell effector differentiation. We performed CUT&Tag followed by seuqencing (CUT&Tag-seq) of ZFP148 in activated CD8+ T cells from healthy C57BL/6J mice to identify direct DNA-binding activity of ZFP148.

ORGANISM(S): Mus musculus

PROVIDER: GSE296311 | GEO | 2026/02/02

REPOSITORIES: GEO

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ZFP148 is a transcriptional regulator of effector CD8+ T cell differentiation [single-cell_multiome]

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ZFP148 is a transcriptional regulator of effector CD8+ T cell differentiation

Project description:ZFP148 is a transcriptional regulator of effector CD8+ T cell differentiation

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dd195318-5103-4c2e-9845-d48e04787b77 - samples

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