Transcriptomics

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HELLS is required for DNA methylation at human satellite repeats [RNA-seq]


ABSTRACT: HELLS is a known chromatin remodeler, but its specific genomic targets have not been sufficiently described. Here, we report the generation of HELLS knockout human pluripotent cells and through telomere-to-telomere mapping of whole genome bisulfite sequencing data combined with ATAC-sequencing, we discovered a striking loss of DNA methylation over inaccessible, satellite repeats. Our study further clarifies the role of HELLS and provides insights into functional consequences through its deregulation in diseases.

ORGANISM(S): Homo sapiens

PROVIDER: GSE296398 | GEO | 2025/06/23

REPOSITORIES: GEO

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