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Chromosome copy number variation in Cryptococcus neoformans influences virulence and occurs in isolates from AIDS patients

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Cryptococcus neoformans var. grubii H99 Cryptococcus neoformans

PROVIDER: GSE29675 | GEO | 2011/06/01

SECONDARY ACCESSION(S): PRJNA141193

REPOSITORIES: GEO

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Chromosome copy number variation in Cryptococcus neoformans influences virulence and occurs in isolates from AIDS patients

Project description:Influence of copy number changes at several chromosomes to melanin production and virulence of Cryptococcus neoformans

2011-04-19 | GSE28673 | GEO

Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients.

Project description: Not available

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Chromosome copy number variation in Cryptococcus neoformans influences virulence and occurs in isolates from AIDS patients

Project description:This SuperSeries is composed of the following subset Series: GSE29627: Chromosome copy number variation in Cryptococcus neoformans influences virulence and occurs in isolates from AIDS patients: CBS7779 black and white strains GSE29671: Chromosome copy number variation in Cryptococcus neoformans influences virulence and occurs in isolates from AIDS patients: clinal and environmental strains Refer to individual Series

2011-05-31 | E-GEOD-29675 | biostudies-arrayexpress

Chromosome copy number variation in Cryptococcus neoformans influences virulence and occurs in isolates from AIDS patients

Project description:Influence of copy number changes at several chromosomes to melanin production and virulence of Cryptococcus neoformans Black(B4) and white(W2) strains were compared to each other. Black variant from white strain (W2BA1) is also compared to the black strain(B4).

2011-04-19 | E-GEOD-28673 | biostudies-arrayexpress

Chromosome copy number variation in Cryptococcus neoformans influences virulence and occurs in isolates from AIDS patients: clinal and environmental strains

Project description:The adaptation of fungal pathogens to the host environment via large-scale genomic changes is a poorly characterized phenomenon. We recently discovered clinical strains of Cryptococcus neoformans, the leading cause of fungal meningoencephalitis in HIV/AIDS patients, which are disomic for chromosome 13. In the current study, we examined the relationship between disomy, expression of the virulence factor melanin and virulence in a mouse model of cryptococcosis. We found that melanin production was correlated with monosomy at chromosome 13, and that disomic variants were less melanized and attenuated for virulence in mice. Changes in the copy number of other chromosomes were also detected in strains showing variation in melanin formation after growth in culture and after passage through mice. A survey of environmental and clinical isolates maintained in culture revealed few occurrences of disomic chromosomes. However, an examination of isolates that were freshly collected from the cerebral spinal fluid of AIDS patients and minimally cultured provided evidence for mixed infections and copy number variation. Overall, these results suggest that the genome of C. neoformans exhibits a greater degree of plasticity than previously appreciated. Importantly, genome variation is associated with virulence factor expression and disease severity, and its occurrence in isolates from AIDS patients suggests that it may have clinical relevance.

2011-06-01 | GSE29671 | GEO

Chromosome copy number variation in Cryptococcus neoformans influences virulence and occurs in isolates from AIDS patients: CBS7779 black and white strains

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Chromosome copy number variation in Cryptococcus neoformans influences virulence and occurs in isolates from AIDS patients: clinal and environmental strains

2011-05-31 | E-GEOD-29671 | biostudies-arrayexpress

Chromosome copy number variation in Cryptococcus neoformans influences virulence and occurs in isolates from AIDS patients: CBS7779 black and white strains

2011-05-30 | E-GEOD-29627 | biostudies-arrayexpress

Project description: Not available

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Comparative hybridization reveals extensive genome variation in the AIDS-associated pathogen Cryptococcus neoformans.

Project description: Not available

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