Novel Epigenetic Mechanisms of Endogenous CSE/H₂S in Smooth Muscle Cells for Abdominal Aortic Aneurysm [ChIP-Seq]

ABSTRACT: In this study, ChIP - seq was employed to investigate the impact of CSE on epigenetic modifications in vascular smooth muscle cells (VSMCs) and to uncover its influence on genome - wide DNA binding. We conducted ChIP - seq experiments on H3K9me3, H3K9ac, and H3K4me3 using primary smooth muscle cells from CSE knockout mice and wild - type (WT) mice after 24 - hour stimulation with Ang II. Our finding demonstrated that endogenous CSE/H₂S in smooth muscle regulates the expression of extracellular matrix through epigenetic modifications and participates in the occurrence and development of abdominal aortic aneurysm (AAA).

ORGANISM(S): Mus musculus

PROVIDER: GSE296864 | GEO | 2026/02/19

REPOSITORIES: GEO