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Effect of a natural product derivative on gene expression signatures in 5xFAD transgenic mice

ABSTRACT: To investigate how a natural product analog mitigates AD, cortical transcriptomes from WT and 5xFAD mice were analyzed. Comparing vehicle-treated groups revealed extensive differential expression associated with neuroinflammation in 5xFAD mice. This was attenuated in the 5xFAD mice treated with the natural product, whose profiles resembled WT controls. RNA seq suggested the natural product regulated the nervous and immune systems.

ORGANISM(S): Mus musculus

PROVIDER: GSE296886 | GEO | 2025/05/13

REPOSITORIES: GEO

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