The RNA-Binding Protein DDX39B Promotes Colorectal Adenocarcinoma Progression by Stabilizing DCLK1

ABSTRACT: As an RNA-binding protein (RBP), DDX39B increased the stability of DCLK1-B mRNA, a variant highly expressed in colorectal cancer known to promote cancer stemness, thereby augmenting its protein expression. Notably, silencing of DCLK1-B effectively abrogated the pro-metastatic effects induced by DDX39B overexpression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE296923 | GEO | 2025/06/22

REPOSITORIES: GEO