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H4K16 acylations fine-tune transcriptional response to short-chain acyl-CoA dehydrogenase deficiency (RNA-seq)

ABSTRACT: We investigated the combined effects of H4K16 acylations in vivo using a mouse model of short-chain acyl-CoA dehydrogenase deficiency (SCADD), which causes metabolic challenges and systemic shifts in acyl-CoA ratios. Our findings indicate that H4K16 acylations modulate transcriptional responses in a concerted manner, providing insights into an adaptive chromatin regulation in response to metabolic stress.

ORGANISM(S): Mus musculus

PROVIDER: GSE296978 | GEO | 2026/01/13

REPOSITORIES: GEO

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H4K16 acylations fine-tune transcriptional response to short-chain acyl-CoA dehydrogenase deficiency (ATAC-seq)

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