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Bulk RNAseq from the medial amygdala of male and female mice

ABSTRACT: Sexual dimorphism in the brain is well-documented, yet clear binary features akin to genital differences remain elusive. Using the TRAP2 transgenic mouse line to track cFos-driven neuronal activity, we identified a distinct cluster of neurons (~200 µm) in the posterodorsal medial amygdala—termed the DIMPLE—that exhibited binary activation: consistently labeled in females but absent in adult virgin males. This pattern was unaffected by gonadectomy but was present in juvenile males before weaning and re-emerged in adult males after mating. Public RNA-seq data showed prolactin receptor enrichment in this region, and exogenous prolactin administration activated DIMPLE in virgin males. We propose that DIMPLE may support neural mechanisms related to female-typical behavior or paternal readiness.

ORGANISM(S): Mus musculus

PROVIDER: GSE297014 | GEO | 2025/06/25

REPOSITORIES: GEO

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