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Next Generation Sequencing Facilitates Quantitative Analysis of Cornea Tissues from Lut Treated and Vehicle Control Treated EDE Mice

ABSTRACT: We had one goal to perform this study: transcriptome of cornea tissues from Lut treated and vehicle control treated EDE mice

ORGANISM(S): Mus musculus

PROVIDER: GSE297118 | GEO | 2025/12/31

REPOSITORIES: GEO

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Next Generation Sequencing Facilitates Quantitative Analysis of Cornea Tissues from Lut Treated and Vehicle Control Treated EDE Mice

Project description:Next Generation Sequencing Facilitates Quantitative Analysis of Cornea Tissues from Lut Treated and Vehicle Control Treated EDE Mice

| PRJNA1262817 | ENA

Next Generation Sequencing Facilitates Quantitative Analysis of Vehicle Control and Vismodegib Treated Tumor Transcriptomes

Project description:Purpose: The goal of this study is to compare transcriptome profiling (RNA-seq) between tumors of mammary tumor bearing mice treated with a vehicle control or FDA approved Hedgehog signaling inhibitor, Vismodegib.

2023-02-01 | GSE146222 | GEO

Next Generation Sequencing Facilitates Quantitative Analysis of Vehicle Control and Vismodegib Treated Tumor Transcriptomes II

2021-11-10 | GSE171168 | GEO

Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and RELA-/- Cornea Transcriptomes [6 months]

Project description:The goals of this study are to compare rela ablate cornea

2021-06-09 | GSE161432 | GEO

Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and RELA-/- Cornea Transcriptomes [2 months]

Project description:The goals of this study are to compare rela ablate cornea

2021-06-09 | GSE161431 | GEO

Next Generation Sequencing Facilitates Quantitative Analysis of Vehicle Control and Vismodegib Treated Tumor Transcriptomes

Project description:Next Generation Sequencing Facilitates Quantitative Analysis of Vehicle Control and Vismodegib Treated Tumor Transcriptomes

| PRJNA609731 | ENA

Next Generation Sequencing Facilitates Quantitative Analysis of Vehicle Control and Vismodegib Treated Tumor Transcriptomes II

Project description:Next Generation Sequencing Facilitates Quantitative Analysis of Vehicle Control and Vismodegib Treated Tumor Transcriptomes II

| PRJNA718581 | ENA

Next Generation Sequencing Facilitates Quantitative Analysis of IFN-γ induced-MMP2/9 inhibition compared to vehicle control cells' Transcriptomes

Project description:Expression profiles of SB-3CT treated A375 human melanoma cell lines and vehicle control group with or without induced by IFN-γ.

2020-09-03 | GSE141585 | GEO

Quantitative metabolomic analysis of the human cornea and aqueous humor

Project description:INTRODUCTION: Cornea is the outermost part of the eye supplied mostly by aqueous humor (AH). Therefore, the comparison of the metabolomic compositions of AH and cornea may help to determine which compounds are produced inside the cornea, and which penetrate into cornea from AH for intra-corneal consumption. Keratoconus (KC) is the most common form of the cornea dystrophy, and the analysis of KC corneas can unravel the metabolomic changes occurring in AH and cornea of KC patients. OBJECTIVES: The work is aimed at the determination of concentrations of a wide range of metabolites in the human cornea and AH, the comparison of the metabolomic profiles of cornea and AH, and the comparison of the metabolomic compositions of samples taken from KC patients and normal donors (post-mortem). METHODS: The quantitative metabolomic profiling was carried out with the use of two independent methods—high-frequency 1H NMR spectroscopy and HPLC with high-resolution ESI-MS detection. RESULTS: The concentrations of 71 most abundant metabolites in cornea and AH from keratoconus patients and from human cadavers have been measured. It is found that the concentrations of purines and organic acids in cornea are significantly higher than in AH. The KC corneas are characterized by the enhanced levels of acetate and citrate, and also by low values of GSH/GSSG ratios. CONCLUSION: A significant difference in the metabolomic compositions of the human AH and cornea has been revealed. The concentrations of glucose and some amino acids in cornea are significantly lower than in AH, indicating their fast consumption inside the cornea. The high levels of organic acids, purines and GSH in cornea should be attributed to their production in the cornea. The enhanced levels of acetate and citrate as well as the low values of GSH/GSSG ratios in KC corneas are the indicators of the oxidative stress.

2018-06-20 | MTBLS444 | MetaboLights

Next Generation Sequencing Facilitates Quantitative Analysis of transcriptomes of human cord blood CD34+ cells treated with HDAC5 inhibitor

Project description:We have used RNA-seq based transcriptome characterization to analyze differentiated gene expression in human cord blood CD34+ cells treated with vehicle control or HDAC5 inhibitor LMK235

2018-03-15 | GSE110736 | GEO

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