Exosomes isolated from M.tb infected cells modulate macrophage response to IFN-gamma

ABSTRACT: we studied the role of exosomes isolated from M.tb infected macrophages in modulating the macrophage response to IFN-γ. Nimblegen microarray gene expression studies were used to compare the suppression of IFN-γ inducible genes by exosomes relative to the virulent strain of M.tuberculosis. Overall our study suggest that exosomes, as carriers of M.tb pathogen associated molecular patterns (PAMPs), may provide a mechanistic link by which M.tb may exert its suppression of host immune response beyond the infected cell, and implies a physiological role for exosomes in immune surveillance of TB.

ORGANISM(S): Mus musculus

PROVIDER: GSE29731 | GEO | 2011/06/05

SECONDARY ACCESSION(S): PRJNA141149

REPOSITORIES: GEO