Transcriptomics

Dataset Information

0

O-GlcNAc transferase senses influenza viral RNA and restricts viral infection by integrating innate immunity and lipid metabolism


ABSTRACT: Viral infection induces robust reprogramming of metabolic pathways in host cells. However, whether host metabolic enzymes detect viral components remains unknown. Our group and others previously identified O-GlcNAc transferase (OGT), an important glucose metabolic enzyme, as a crucial mediator of the antiviral immune responses. Here, we discover an enzyme-independent function of OGT in restraining influenza A virus (IAV) infection in addition to its enzyme-dependent effect on MAVS-mediated antiviral immunity by studying a mouse model with an enzyme-inactive OGT. Biochemical studies reveal a critical antiviral effect based on OGT N-terminal tetracopeptide repeat-4-domain binding to IAV genomic RNA. This binding causes the translocation of nuclear OGT to cytosolic lipid droplets (LDs) to destabilize LDs-coating perilipin 2, thereby limiting LDs accumulation and in turn virus replication. In sum, our findings reveal OGT as a multifaceted metabolic sensor that integrates MAVS signaling and lipid metabolism to combat viral infection.

ORGANISM(S): Homo sapiens

PROVIDER: GSE297354 | GEO | 2025/07/15

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2025-02-06 | MSV000097062 | MassIVE
2024-09-10 | PXD054077 | Pride
2014-04-15 | E-GEOD-56783 | biostudies-arrayexpress
2020-12-10 | GSE142499 | GEO
2025-03-07 | PXD051850 | Pride
2015-12-08 | E-GEOD-57508 | biostudies-arrayexpress
2021-06-20 | GSE161878 | GEO
2025-04-30 | GSE293066 | GEO
2017-08-01 | GSE96774 | GEO
2022-05-20 | PXD031993 | Pride