Endothelial CEPT1 Promotes Angiogenesis Through PPAR and VEGF-A Signaling

ABSTRACT: Cept1 is essential for de novo phopholipogenesis and is impacted by diabetes. We previously demonstrated that conditional knockdown of Cept1 in the endothelium leads to reduced tissue recovery. Therefore, we hypothesized that Cept1 may also be sufficient in promoting post-ischemic angiogenesis and recovery in the setting of diabetes. We have employed a single cell sequencing approach using 10x Genomics scRNAseq to study the role of Cept1 overexpression in mice aortic tissue.

ORGANISM(S): Mus musculus

PROVIDER: GSE297688 | GEO | 2025/11/20

REPOSITORIES: GEO