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ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE297837 | GEO | 2026/05/01

REPOSITORIES: GEO

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ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment

Project description:Short interspersed nuclear elements (SINEs) are abundant non-autonomous transposable elements derived from RNA polymerase III (Pol III)-transcribed short non-coding RNAs. SINEs retain sequence features recognized by the Pol III machinery and constitute a substantial portion of vertebrate genomes. Despite their impact on genome stability and evolution, the mechanisms governing SINE transcription remain poorly understood. Although DNA methylation and heterochromatin formation have been implicated in their repression, we find these pathways play only a minor role in mouse embryonic stem cells. Instead, we identify the ChAHP complex as a key repressor of SINE B2 elements. ChAHP directly inhibits Pol III transcription by blocking TFIIIB recruitment without affecting TFIIIC binding. This selective interference prevents transcription initiation and highlights a distinct regulatory mechanism. Our findings establish ChAHP as a non-canonical repressor of Pol III-dependent SINE transcription, offering new insights into the control of this pervasive class of non-coding genomic elements.

2026-06-30 | PXD064515 | Pride

ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment [ChIP-seq]

Project description:Short interspersed nuclear elements (SINEs) are abundant non-autonomous transposable elements (TEs) derived from RNA polymerase III (Pol III)-transcribed short non-coding RNAs. SINEs retain sequence features recognized by the Pol III machinery and constitute a substantial portion of vertebrate genomes. Despite their impact on genome stability and evolution, the mechanisms governing SINE transcription remain poorly understood. Although DNA methylation and heterochromatin formation have been implicated in their repression, we find these pathways play only a minor role in mouse embryonic stem cells. Instead, we identify the ChAHP complex as a key repressor of SINE B2 elements. ChAHP directly inhibits Pol III transcription by blocking TFIIIB recruitment without affecting TFIIIC binding. This selective interference prevents transcription initiation and highlights a distinct regulatory mechanism. Our findings establish ChAHP as a non-canonical repressor of Pol III-dependent SINE transcription, offering new insights into the control of this pervasive class of non-coding genomic elements.

2026-05-01 | GSE297834 | GEO

ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment [RNA-seq]

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ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment.

Project description:ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment.

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ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment [RNA-seq]

Project description:ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment [RNA-seq]

| PRJNA1266249 | ENA

ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment [ChIP-seq]

Project description:ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment [ChIP-seq]

| PRJNA1266252 | ENA