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ChAHP Displaces Transcriptional Regulators Through Active Chromatin Remodeling

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE297864 | GEO | 2025/07/21

REPOSITORIES: GEO

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ChAHP Displaces Transcriptional Regulators Through Active Chromatin Remodeling [RNAseq]

Project description:Transcriptional control in eukaryotes relies on the coordinated action of chromatin-based regulatory mechanisms, including control of nucleosome occupancy and chromatin modifications. We previously identified the ChAHP complex – comprising the chromatin remodeler CHD4, transcription factor ADNP, and HP1 proteins – as a repressor of SINE B2 retrotransposons and site-specific regulator of CTCF engagement with chromatin. However, the molecular basis of these functions remained unresolved. Here, we show that ChAHP-associated CHD4 is essential for SINE B2 repression, while HP1 proteins are dispensable. We further demonstrate that CHD4’s remodeling activity is not required for chromatin binding, but is critical for both retrotransposon silencing and efficient CTCF antagonism. We propose ChAHP is a sequence-specific recruiter of chromatin remodeling activity, facilitating transcriptional control and localized modulation of chromatin architecture.

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ChAHP Displaces Transcriptional Regulators Through Active Chromatin Remodeling [ChIPseq]

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ChAHP Displaces Transcriptional Regulators Through Active Chromatin Remodeling

Project description:ChAHP Displaces Transcriptional Regulators Through Active Chromatin Remodeling

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ChAHP Displaces Transcriptional Regulators Through Active Chromatin Remodeling [RNAseq]

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