Adipocyte-Specific IGF1R Knockout Activates the β-Catenin/Apelin Axis to Combat Diet-Induced Obesity

ABSTRACT: Obesity, driven by complex genetic and environmental interactions, remains a global health crisis with limited therapeutic options. The insulin-like growth factor 1 receptor (IGF1R) plays dual roles in metabolism and growth, but its tissue-specific functions in adipose biology are controversial. This study investigates how adipose-specific IGF1R knockout impacts systemic metabolism under high-fat diet (HFD) stress and explores the underlying mechanisms.

ORGANISM(S): Mus musculus

PROVIDER: GSE298110 | GEO | 2025/06/03

REPOSITORIES: GEO