Transcriptomic profiling of cardiac lymphatic endothelial cells in autoimmune myocarditis

ABSTRACT: This study investigates how cardiac lymphatic endothelial cells (LECs) respond to VEGF-C stimulation during autoimmune myocarditis in mice. The tissue from mouse hearts 3 weeks after disease induction and analyzed via bulk RNA sequencing. VEGF-C treatment significantly altered immune-related gene expression, particularly in macrophage regulatory pathways, highlighting lymphatic immunomodulation in myocarditis.

ORGANISM(S): Mus musculus

PROVIDER: GSE298225 | GEO | 2025/10/31

REPOSITORIES: GEO