Transcriptomics

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Single-cell RNA-seq of peripheral blood mononuclear cells from kidney-transplant recipients with stable renal function versus graft dysfunction


ABSTRACT: Kidney transplantation restores renal function in patients with end-stage renal disease, yet long-term graft failure remains common and is often driven by immune dysregulation. We performed droplet-based single-cell RNA sequencing (10x Genomics 3′ v3 chemistry) on peripheral-blood mononuclear cells (PBMCs) collected from adult kidney-transplant recipients who either maintained stable renal function (Ctrl, n = 10) or displayed biopsy-proven graft dysfunction (PTRI, n = 10).

ORGANISM(S): Homo sapiens

PROVIDER: GSE298312 | GEO | 2025/07/02

REPOSITORIES: GEO

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