Microgravity Accelerates Skeletal Muscle Degeneration: Functional and Transcriptomic Insights from a Muscle Lab-on-Chip Model Onboard the ISS.

ABSTRACT: Global transcriptomic analysis revealed increased gene expression and particularly mitochondrial-related gene expression in microgravity for the electrically stimulated younger myobundles, while the older myobundles were less responsive. Young- and old-derived skeletal muscle myobundles were exposed to microgravity for 12 days and matching ground control group.

ORGANISM(S): Homo sapiens

PROVIDER: GSE298393 | GEO | 2025/07/30

REPOSITORIES: GEO