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Myeloid cell METTL1 deletion significantly mitigated CLP-induced multiple organ injury and I/ R-induced kidney injury

ABSTRACT: 1. METTL1 expression was upregulated in monocytes/macrophages during acute inflammation. 2. Myeloid METTL1 depletion alleviated tissue damage induced by CLP and I/R. 3. METTL1 promoted infiltration and pro-inflammatory differentiation of macrophages. 4. SARM1-induced NAD+ consumption is crucial for the METTL1-induced metabolic reprogramming of macrophages. 5. SA91-0178, a METTL1 inhibitor, effectively alleviated injuries induced by CLP and I/R.

ORGANISM(S): Homo sapiens

PROVIDER: GSE298503 | GEO | 2025/06/02

REPOSITORIES: GEO

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