Murine oligodendrocyte-derived glioblastoma induced by oncogenic lentivirus in CNP-Cre mice.

ABSTRACT: Using a CNP-Cre transgenic mouse model, this study investigates the role of differentiated oligodendrocytes as a candidate cell-of-origin for GBM. We show that these cells can give rise to GBM tumors when targeted with Cre-inducible oncogenic lentiviral vectors expressing PDGFB and shP53 or HRasV12 and shp53

ORGANISM(S): Mus musculus

PROVIDER: GSE298515 | GEO | 2026/05/29

REPOSITORIES: GEO