Enhanced Differentiation Potential of Pigmented Human Epidermal Equivalents

ABSTRACT: Melanocyte-keratinocyte interactions are vital for regulating melanogenesis and maintaining epidermal homeostasis. However, most 3D human skin equivalents lack melanocytes, limiting their relevance for pigmentation studies. To address this, we utilized a pigmented human epidermal equivalent (PmtHEE) that incorporates melanocytes into the epidermis. Using single-cell RNA sequencing (scRNA-seq), we characterized PmtHEE and compared it with neonatal foreskin epidermis (FsEpi) and a fibroblast-containing human skin equivalent model (FibHSE).

ORGANISM(S): Homo sapiens

PROVIDER: GSE298681 | GEO | 2026/05/27

REPOSITORIES: GEO