Host- and echinocandin-induced stresses exert profound cell wall changes in Candida parapsilosis, conferring echinocandin tolerance and retaining fitness

ABSTRACT: In this study, we compared transcriptomic changes in four serial isolates of Candida parapsilosis from a single patient over three time points (90 minutes, 8 hours and 24 hours) and two growth conditions (biofilm and planktonic). The later serial isolates have increased fitness and are resistant to echinocandins compared to the initial strain. Using RNA-Seq, we identified strain-specific changes in expression of specific biological processes and cellular components including fungal-type cell wall and transmembrane transport.

ORGANISM(S): Lodderomyces parapsilosis

PROVIDER: GSE298776 | GEO | 2025/12/31

REPOSITORIES: GEO