Transcription Factor 25 Modulates Gametocytogenesis in the Malaria Parasite Plasmodium falciparum [RNA-Seq]

ABSTRACT: This study elucidates the role of TCF25 as a transcriptional regulator orchestrating sexual conversion in Plasmodium falciparum. Through generation of isogenic tcf25_ko parasite lines, we performed comparative transcriptomic analysis of synchronized ring-stage and schizont-stage parasites (WT vs knockout). Our data demonstrate that tcf25 deletion causes significant dysregulation of both gametocytogenesis-associated genes and antigenic variation gene families. TCF25 directly binds a sexual conversion regulator ap2-g4. These results indicate TCF25 as an essential upstream regulator of malaria parasite sexual development and potential transmission-blocking target.

ORGANISM(S): Plasmodium falciparum

PROVIDER: GSE298805 | GEO | 2025/08/20

REPOSITORIES: GEO