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Elucidating the mechanisms underlying KRT19 contributes to NSCLC progression

ABSTRACT: As a member of the acidic type I cytokeratin family, keratin 19 (KRT19) is originally known to form the intermediate filament cytoskeleton and responsible for structural rigidity and multipurpose scaffolds.KRT19 is abnormally expressed in various cancers including hepatocellular carcinoma, breast cancer,serous ovarian cystadenocarcinoma and et.al. KRT19 has been revealed to mediate cell cycle, cancer stem cell reprogramming by interacting with cellular molecules including receptors, adaptors, effectors and kinases. Increasing evidence illustrates the clinical significance of KRT19 in lung cancer, extensive studies are urged to elucidate the role and underlying mechanism of KRT19 in NSCLC progression, we performed RNA-Seq to identify its target genes in A549 cell lines.

ORGANISM(S): Homo sapiens

PROVIDER: GSE298926 | GEO | 2026/01/21

REPOSITORIES: GEO

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Elucidating the mechanisms underlying KRT19 contributes to NSCLC progression [PC-9 cells_RNA-Seq]

Project description:As a member of the acidic type I cytokeratin family, keratin 19 (KRT19) is originally known to form the intermediate filament cytoskeleton and responsible for structural rigidity and multipurpose scaffolds.KRT19 is abnormally expressed in various cancers including hepatocellular carcinoma, breast cancer,serous ovarian cystadenocarcinoma and et.al. KRT19 has been revealed to mediate cell cycle arrest, cancer stem cell reprogramming by interacting with cellular molecules including receptors, adaptors, effectors and kinases. Increasing evidence illustrates the clinical significance of KRT19 in lung cancer, extensive studies are urged to elucidate the role and underlying mechanism of KRT19 in NSCLC progression, we performed RNA-Seq to identify its target genes in PC-9 cell lines.

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