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Aberrant Cell Fate and Functional Impairment in Developing Human Liver Organoids Exposed to Nanoplastics

ABSTRACT: Nanoplastics represent an emerging class of global environmental contaminants; however, their potential to interfere with human developmental processes remains largely unexplored. This study investigated the impact of exposure to polystyrene nanoplastics (PS-NP) on the de novo formation, differentiation, and function of human liver organoids derived from induced pluripotent stem cells (hiPSCs), a sophisticated model of early organogenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE298927 | GEO | 2025/12/01

REPOSITORIES: GEO

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Oral ingestion of polystyrene nanoplastics causes memory impairment and neuroinflammation by microglial uptake

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