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Organism-wide contributions to systemic skeletal muscle repair in larval zebrafish.

ABSTRACT: We developed a systemic muscle injury model in zebrafish. Single cell transcriptomic analysis of muscle and non-muscle tissues revealed that systemic and local muscle injuries elicit distinct cellular molecular responses, both quantitatively and qualitatively. These studies suggest that large- and small-scale muscle injuries activate different regenerative programs, resulting in either systemic or local repair.

ORGANISM(S): Danio rerio

PROVIDER: GSE299146 | GEO | 2025/06/10

REPOSITORIES: GEO

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