Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression changes in Ctcf-deleted mouse uterus on gestational day 4 (GD4).

ABSTRACT: We specifically deleted Ctcf in the female reproductive tract using the Pgr-Cre driver. To portray the molecular mechanism for Ctcf function in uterus, uterine tissues were collected from Ctcf f/f and Ctcf d/d mice on GD4 and subjected to RNA-seq analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE299181 | GEO | 2025/06/11

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene expression changes in Mettl3-deleted mouse uterus on gestational day 4

Project description:We specifically deleted Mettl3 in the female reproductive tract using the Pgr-Cre driver. To portray the molecular mechanism for Mettl3 function in uterus, uterine tissues were collected from Mettl3f/f and Mettl3d/d mice on gestational day 4 and subjected to RNA-seq analysis.

2022-11-18 | GSE211614 | GEO

Gene expression changes in conditional METTL3 overexpression mouse uterus compared to control mouse uterus on gestational day 8

Project description:We specifically over-expressed Mettl3 in mouse uterus using the Pgr-Cre driver. To portray the molecular mechanism for Mettl3 function in mouse uterus during decidualization, uterine tissues were collected from METTL3-OE and control mice on gestational day 8 and subjected to RNA-seq analysis.

2024-04-14 | GSE263332 | GEO

Gene expression changes in Mettl14d/d mouse uterus compared to Mettl14f/f mouse uterus on gestational day 4 [RNA-seq]

Project description:We specifically deleted Mettl14 in mouse uterus using the Pgr-Cre driver. To portray the molecular mechanism for Mettl14 function in mouse uterus, uterine tissues were collected from Mettl14f/f and Mettl14d/d mice on gestational day 4 and subjected to RNA-seq analysis.

2024-04-12 | GSE263378 | GEO

Single-cell RNA-seq analysis of Mettl14d/d mouse uterus compared to Mettl14f/f mouse uterus on gestational day 4

2024-04-25 | GSE264490 | GEO

Gene expression changes in Nat10-deleted mouse uterus on PND21

Project description:We specifically deleted Nat10 in the female reproductive tract using the Pgr-Cre driver. To portray the molecular mechanism for Nat10 function in uterus, uterine tissues were collected from Nat10f/f and Nat10d/d mice on PND21 and subjected to RNA-seq analysis.

2025-04-15 | GSE293346 | GEO

Gene expression changes in Mettl3ed/ed mouse uterus compared to Mettl3f/f mouse uterus on gestational day 4

Project description:We specifically deleted Mettl3 in the epithelium of mouse uterus using the Ltf-Cre driver. To portray the molecular mechanism for Mettl3 function in uterine epithelium, uterine tissues were collected from Mettl3f/f and Mettl3ed/ed mice on gestational day 4 and subjected to RNA-seq analysis.

2024-04-03 | GSE262806 | GEO

CTCF ChIPseq of mouse uterus

Project description:Receptors for estrogen and progesterone frequently interact, via Cohesin/CTCF loop extrusion, at enhancers distal from regulated genes; CTCF is decreased or mutated in >20% of human endometrial tumors, indicating its importance in uterine homeostasis. To better understand how CTCF-mediated enhancer-gene interactions impact endometrial development and function, the Ctcf gene was selectively deleted in female reproductive tissues of mice. Prepubertal Ctcfd/d uterine tissue exhibited normal morphology, with a significant reduction in the number of uterine glands compared to those without Ctcf deletion (Ctcff/f mice). Post-pubertal Ctcfd/d uteri were hypoplastic with significant reduction in both the size of the endometrial stroma and number of glands. Transcriptional profiling revealed increased expression of stem cell molecules Lif, EOMES and Lgr5, and enhanced inflammation pathways following Ctcf deletion. Analysis of the response of the uterus to steroid hormone stimulation showed that the response of the uterus to estrogen was not impacted, but that CTCF deletion affects a subset of progesterone responsive genes. This finding indicates 1) mediators of P signaling remain functional following Ctcf deletion and 2) certain P regulated genes are sensitive to Ctcf deletion, suggesting they depend on gene-enhancer interactions that require CTCF. The P responsive genes altered by CTCF ablation included Ihh, Fst and Errfi1, as well as other genes involved in the regulation of critical processes including hormone response, transcription, and inhibition of tumor generation. Overall, our findings reveal that uterine Ctcf plays a key role in P dependent expression of uterine genes underlying optimal post pubertal uterine development.

2024-08-08 | GSE227519 | GEO

Gene expression changes in Mettl3-deleted mouse oviduct on gestational day 3

Project description:We specifically deleted Mettl3 in the female reproductive tract using the Pgr-Cre driver. To portray the molecular mechanism for Mettl3 function in oviduct, whole oviduct were collected from Mettl3f/f and Mettl3d/d mice on gestational day 3 and subjected to RNA-seq analysis.

2022-11-18 | GSE217174 | GEO

Gene expression changes in Ctcf-deleted mouse uterus on gestational day 4 (GD4).

Project description:Gene expression changes in Ctcf-deleted mouse uterus on gestational day 4 (GD4).

| PRJNA1273034 | ENA

CTCF ChIPseq of mouse uterus

Project description:CTCF ChIPseq of mouse uterus

| PRJNA945440 | ENA