ABSTRACT: Tris(2-butoxyethyl) phosphate (TBOEP) is a common organophosphorus compound widely used in industrial production as a plasticizer and flame retardant. In recent years, studies have shown that TBOEP may pose potential threats to human health, particularly its association with kidney metabolic function has attracted widespread attention. The kidneys, as the most important metabolic organ in the human body, play a crucial role in detoxification, synthesis, and decomposition of various biomolecules. After entering the human body, TBOEP is mainly metabolized and detoxified by the kidneys. However, TBOEP and its metabolites may interfere with the normal function of the kidneys, leading to metabolic disorders. Studies have shown that TBOEP exposure may affect the activity of enzymes in the kidneys, such as cytochrome P450 enzyme systems, which are involved in the metabolism of various endogenous and exogenous substances. In addition, TBOEP may also affect kidney metabolism by influencing gene expression. For example, TBOEP exposure may activate or inhibit genes related to lipid metabolism, glucose metabolism, and oxidative stress, thereby altering the metabolic state of the kidneys. These changes not only affect the function of the kidneys themselves but may also have a chain reaction on the health of other organs and systems through the interaction of the systemic metabolic network. Furthermore, TBOEP exposure may lead to kidney damage and dysfunction, which can further exacerbate metabolic disorders. For example, kidney damage can impair the excretion of metabolic waste products, leading to their accumulation in the body and further disrupting metabolic balance. In summary, as an environmental pollutant, the potential impact of TBOEP on kidney metabolic function cannot be ignored. Future research needs to further explore the toxicological mechanisms of TBOEP and its long-term effects on human health in order to develop effective prevention and intervention measures to protect public health.
