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Analysis and statistics of mRNA interacting with 7F2-positive microtubule associating protein tau in human hippocampal Alzheimer’s Disease tissue.

ABSTRACT: The microtubule associating protien tau, (MAPT, tau) is a primary pathologic factor in a number of neurodegenerative disorders, including Alzheimer's Disease. Tau can interact with RNA. These interactions have been proposed as initiating factors for the formation of the pathological forms of tau noted in diseases. Additionally, it has been suggested that the m6A-methylation state of RNA is a factor in the association of RNA to tau. This study uses enhanced crosslinking immunoprecipitation (eCLIP) techniques to 1) identify, quantify, a sequence the RNA species interacting with the tau protein isolated from Alzheimers disease human hippocampal tissue, 2) identify, quantify, and sequence the methylated RNA in Alzheimer's disease human hippocampal tissue, and 3) to look for associations between the RNAs that interact with tau and RNA methylation status.

ORGANISM(S): Homo sapiens

PROVIDER: GSE299571 | GEO | 2026/06/30

REPOSITORIES: GEO

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m6A-methylation analysis and statistics of mRNA interacting with microtubule associating protein tau in human hippocampal Alzheimer’s Disease tissue.

Project description:The microtubule associating protien tau, (MAPT, tau) is a primary pathologic factor in a number of neurodegenerative disorders, including Alzheimer's Disease. Tau can interact with RNA. These interactions have been proposed as initiating factors for the formation of the pathological forms of tau noted in diseases. Additionally, it has been suggested that the m6A-methylation state of RNA is a factor in the association of RNA to tau. This study uses enhanced crosslinking immunoprecipitation (eCLIP) techniques to 1) identify, quantify, a sequence the RNA species interacting with the tau protein isolated from Alzheimers disease human hippocampal tissue, 2) identify, quantify, and sequence the methylated RNA in Alzheimer's disease human hippocampal tissue, and 3) to look for associations between the RNAs that interact with tau and RNA methylation status.

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