Dataset Information


MicroRNA expression in Barrett's esophagus and esophageal adenocarcinoma

ABSTRACT: Barrett's esophagus is a metaplastic condition of the distal esophagus, characterized by the replacement of normal squamous epithelium by columnar epithelium. Patients with BE have an increased risk of developing esophageal adenocarcinoma. MicroRNAs have been implicated to be disease and tissue specific, however limited data of microRNA expression in the esophagus is available. Therefore we evaluated microRNA expression profiles of esophageal adenocarcinoma and compared these with Barrett's esophagus and normal squamous esophagus. Overall design: In total 12 samples were analyzed. 4 esophageal adenocarcinoma, 4 Barrett's esophagus and 4 normal squamous esophagus

INSTRUMENT(S): miRCURY LNA microRNA Array, v.10.0 - hsa, mmu & rno

SUBMITTER: Jantine Wilhelmina Paula Maria van Baal  

PROVIDER: GSE29965 | GEO | 2012-03-15



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OBJECTIVE: Barrett's oesophagus (BE) is a metaplastic condition of the distal oesophagus which predisposes to oesophageal adenocarcinoma (EAC). It has been suggested that microRNAs (miRNAs) are involved in the process of development of BE and EAC; however, few functional miRNA data are available. The aim of the study was to perform a tissue-specific miRNA profile and, based on this, to examine the function of miRNA-145 in the oesophagus. DESIGN: miRNA expression profiling using microarray analys  ...[more]

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