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GATA Transcription Factors Coordinate Developmental Progression in the Arabidopsis Root

ABSTRACT: For proper organ development, cell proliferation and cellular differentiation must balance in a tightly regulated spatiotemporal manner. Here, we show that a phased gene expression profile from meristematic cells at the Arabidopsis root niche, to differentiating cortex- and endodermis cells, is defined by the action of distinct transcription factor (TF) families. We show that while chromatin accessibility serves as a strong predictor of the activation of developmental genes, a key expression ‘switch’ from dividing- to elongating/differentiating cells is underpinned by a considerable level of chromatin rearrangement. Within this structure, a GATA TF subfamily is proposed to sit at the heart of a mutually antagonistic regulatory module, acting to promote differentiation and feedback on cell proliferation through the regulation of both lineage specific differentiation processes and general maturation programs. Key to this is integration of the auxin- and cytokinin responsive PLT- and ARR-B TF families. This model provides a level of coordination in the regulation of meristem size and the timing of differentiation, at both the tissue- and organ levels.

ORGANISM(S): Arabidopsis thaliana

PROVIDER: GSE299784 | GEO | 2025/06/20

REPOSITORIES: GEO

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