Transcriptomics

Dataset Information

0

Airway Epithelial SARS-CoV-2 Infectious and Repair Responses: Relationships to Age, Sex, and Post-COVID Pulmonary Syndromes


ABSTRACT: This study investigated the acute and reparative responses as a function of age and sex in primary human bronchial epithelial (HBE) cultures over a 14-day post-SARS-CoV-2 infection (dpi) protocol. Methods: Bulk RNA-seq was performed on well-differentiated human bronchial epithelial (HBE) cell culture lysates with/without SARS-CoV-2 inoculation. Results: SARS-SoV-2 infection peaked at 3 dpi with an ~ 2 log titer suppression at 14 dpi. Airway epithelia repaired to an abnormal mucus metaplastic/inflammatory state that reflected potentially beneficial and adverse consequences at 14 dpi. No age- or sex-dependent effects on SARS-CoV-2 infection were detected. Conclusions: Human airway epithelial repair post-SARS-CoV-2 is prolonged and incomplete in vitro over 14 days, and persistently abnormal repair may contribute to phenotypes of people with long-COVID pulmonary syndrome.

ORGANISM(S): Homo sapiens

PROVIDER: GSE299837 | GEO | 2025/07/18

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-08-03 | GSE210223 | GEO
2020-07-21 | GSE154768 | GEO
2021-02-28 | GSE166766 | GEO
2024-03-26 | GSE262439 | GEO
2022-02-10 | GSE196464 | GEO
2023-12-02 | GSE248773 | GEO
2023-12-02 | GSE248775 | GEO
2021-03-05 | GSE168215 | GEO
2020-11-27 | E-MTAB-9781 | biostudies-arrayexpress
2021-05-29 | GSE175779 | GEO